The Pritikin Program was found to reduce prostate cancer cell growth by as much as 45%, which should drastically reduce the risk for clinical cancer.  Reductions in serum insulin, free testosterone, estradiol, and IGF-1 along with a rise in SHBG and IGFBP-1 appear important.  The decrease in IGF-1 appears to be the most significant change because IGF-1 normally prevents cells from going into apoptosis (cell death).
Barnard, R.J. Cancer of the Prostate, Benign Prostatic Hypertrophy, Diet and Exercise Intervention. www.Vitasearch.com. May, 2008

Studying the effect of dietary fat on prostate cancer development, UCLA researchers found that animals on a low-fat diet (12% calories from fat) were significantly less likely to develop invasive prostate cancer compared to animals on a high-fat diet (42% calories from fat).  
Kobayashi, N., R.J. Barnard, J. Said, J. Hong-Gonzales, D.M. Corman, M. Ku, N.B. Doan, D. Elashoff, P. Cohen, W.J. Aronson. Effect of low fat diet on development of prostate cancer and the Akt pathway. Cancer Res. 68:3066-3073,2008

The Pritikin Program was found to significantly reduce the growth of prostate epithelial cells, which could reduce risk of Benign Prostate Hyperplasis, common among men 50 and older in industrialized societies.
Barnard, R.J., N. Kobayashi, W.J. Aronson. Effect of diet and exercise intervention on the growth of prostate epithelial cells. Prostate Cancer Prostatic Dis. 11:362-366,2008

For significant weight loss and long-term maintenance, UCLA researchers assert importance of regular exercise and a healthy low-fat diet (high in fiber-rich whole foods).
Roberts, C.K., R.J. Barnard, and D.M. Croymans. Correspondence to the Editor: Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet.  New England Journal of Medicine 359 (20): 2169, 2008.

The Pritikin Program Was Shown To:

Reduce Several Risk Factors For Heart Disease In Children
Roberts, C.K., A.K. Chen, R.J. Barnard. Effect of a short-term diet and exercise intervention in youth on atherosclerotic risk factors. Atherosclerosis 191:98-106,2007

Prevention of Prostate Cancer: Soy Supplements Did Not Decrease IGF-I Levels
Dewell, A., G. Weidner, M.D. Sumner, R.J. Barnard, R.O. Marlin, J.J. Daubenmier, P.R. Carroll, D. Ornish. Evaluation of dietary protein and soy isoflavones in relation to serum IGF-I and IGF binding proteins in the Prostate Cancer Lifestyle Trial. Nutrition and Cancer 58:35-42,2007

Reduce Risk of Prostate Cancer
Barnard, R.J. P.S. Leung, W.J. Aronson, P. Cohen, L.A. Golding. A mechanism to explain how regular exercise might reduce the risk for clinical prostate cancer. The European Journal of Cancer Prevention 16:415-421, 2007

Alleviate the Metabolic Syndrome, Which May Help Prevent Prostate Cancer
Barnard, R.J. Prostate cancer prevention by nutritional means to alleviate metabolic syndrome. The American Journal of Clinical Nutrition 86(suppl):889S-893S,2007

The Pritikin Program Was Shown To:

Alleviate the Metabolic Syndrome
Roberts, C.K., D. Won, S. Pruthi, S. Kurtovic, R.K. Sindhu, N.D. Vaziri, R.J. Barnard. Effect of a short-term diet and exercise intervention on oxidative stress, inflammation, MMP-9 and monocyte chemotactic activity in men with metabolic syndrome factors. J Appl Physiol 100:1657-1665,2006; and

Physical Activity and Dietary Intervention for Chronic Diseases: A Quick Fix After All
Booth, F.W., M.V. Chakravarthy. J Appl Physiol (Invited Editorial) 100:143901440,2006

Alleviate the Metabolic Syndrome In Children
Chen, A., C.K. Roberts and R.J. Barnard. Effect of a short-term diet and exercise intervention on metabolic and anthropometric parameters in overweight children and adolescents. Metabolism 55:871-878,2006

Reduce Oxidative Stress, Therefore Reducing the Risk of Heart Attacks and Strokes
Roberts, C.K., R.J. Barnard, R.K. Sindhu, M. Jurczak, A. Ehdaie, N.D. Vaziri. Oxidative stress and dysregulation of NAD(P)H oxidase and anitoxidant enzymes in diet-induced metabolic syndrome. Metabolism 55:928-934,2006

Reduce Oxidative Stress In Diabetic Men, Therefore Reducing the Risk of Heart Attacks and Strokes
Roberts, C.K., D. Won, S. Pruthi, R.J. Barnard Effect of diet and exercise intervention on oxidative stress, inflammation and monocyte adhesion in diabetic men. Diabetes Res. 73:249-259,2006

Retard the Growth of Breast Cancer Cells
Barnard, R.J., J.H. Gonzalez, M. Liva, T.H. Ngo. Effect of a low-fat, high-fiber diet and exercise program on breast cancer risk factors in vivo and tumor cell growth and apoptosis in vitro. Nutrition and Cancer 55:28-34,2006

Improve the Function of HDL Cholesterol
Roberts, C.K., C. Ng, S. Hama, R.J. Barnard. Effect of a diet and exercise intervention on inflammatory/anti-inflammatory properties of HDL in men with cardiovascular risk factors. J. Appl. Physiol. 101:1727-1732,2006

Alleviate the Metabolic Syndrome
Sullivan S, Klein S. Effect of a short-term Pritikin diet therapy on the metabolic syndrome. J Cardio Metab Syndrome. 1:308-312, 2006.

Scientists Affiliated With the Nathan Pritikin Research Foundation Also:

Investigated the Potential Health Benefits of Tea Consumption
Henning, S.M., W. Aronson, Y. Niu, F. Conde, N.H. Lee, N.P. Seeram, R-P. Lee, J. Lu, D.M. Harris, A. Moro, J. Hong, P-S. Leung, R.J. Barnard, H.G. Ziaee, G. Csathy, V.L.W. Go, H. Wang, D. Heber. Bioavailability and bioactivity of tea polyphenols in humans and mice after green and black tea consumption. J Nutr. 136:1839-1843,2006

Investigated the Potential Health Benefits of Pomegranate Juice Consumption
Pantuk, A.J., J.T. Leppert, W. Aronson, J. Hong, R.J. Barnard, N. Seeram, H. Wang, R. Elashoff, D. Heber, L. Ignarro, A. Belldegrun. Phase II study of pomegranate juice for men with rising PSA following surgery or radiation for prostate cancer. Clin. Cancer Res. 12:4018-4026,2006

Studied the Effects of Omega-6/Omega-3 Ratios On Prostate Cancer Cells
Kobayaski, N., R.J. Barnard, S.M. Henning, D. Elashoff, S.T. Reedy, P. Leung, J. Hong-Gonzalez, S.J. Freedland, J. Said, D. Gui, N.P. Seeram, L.M. Popoviciu, D. Bagga, D. Heber, J.A. Glaspy, W.J. Aronson. Effect of Altering Dietary Omega-6: Omega-3 Fatty Acid Ratios on Prostate Cancer Membrane Composition, Cyclooxygenase-2 and Prostaglandin E-2. Clin Cancer Res. 12:4662-4670,2006

High-Fat, Refined Carbohydrate Diet Leads To Inflammation, Heart Disease
Roberts, C.K., R.J. Barnard, R.K. Sindhu, M. Jurczak, A. Ehdaie, N.D. Vasiri. A high-fat, refined carbohydrate diet induces endothelial dysfunction, oxidant/antioxidant imbalance and depresses NO synthase protein expression. J Appl Physiol 98:203-210, 2005.

The Pritikin Program Was Found To Reduce Cancer Cell Growth
Barnard, R.J. and W.J. Aronson. Preclinical models relevant to diet, exercise, and cancer. In: Recent Results in Cancer Research (Controversies in Tumor Prevention and Genetics III). H-J. Senn and R. Morant, eds. Springer 2005, 166:47-62.

The Pritikin Program Was Found To Control Diabetes and Hypertension And, For Many, Eliminate the Need For Drugs
Roberts, C.K. and Barnard, R.J. Effect of diet and exercise on chronic disease. J Appl Physiol 98:3-30, 2005.

Lifestyle Changes Halt Progression of Early-Stage Prostate Cancer
Ornish D, Carroll PR, Fair WR, Pettengill EB, Marlin R, Raisin CJ, Dunn-Emke S, Crutchfield L, Barnard RJ, McCormac P, McNight DJ, Fein JD, Dnstrian AM, Weinstein J, Ngo T, Weidner G. Intensive lifestyle changes may affect the progression of prostate cancer. J Urol 174:1065-1070, 2005.

Low-Fat Diet Was Found To Significantly Prolong Life in Animals With Prostate Cancer
Ngo, T.H., R.J. Barnard, T. Anton, C. Tran, D. Elashoff, D. Heber, S.J. Frieedland and W.J. Aronson. Effect of isocaloric low-fat diet on prostate cancer xenograft progression to androgen independence. Cancer Res. 64:1252-1254, 2004.

The Pritikin Program Was Found To Reduce Inflammation Markers Like C-Reactive Protein On Average 45%
Wegge, J.K.,C.K. Roberts,T.H. Ngo and R.J. Barnard. Effect of diet and exercise intervention on inflammatory markers of atherosclerosis in postmenopausal women. Metabolism 53:377-381, 2004.

Exercise Was Found To Combat Negative Effects of Poor Diet On Nervous System
Molteni, R., A. Wu, S. Vaynmam, R.J.Barnard and F.Gomez-Pinilla. Voluntary physical activity compensates for the deleterious effects of a high-fat, refined-sugar diet on behavioral and neuronal plasticity. Neuroscience 123:429-440, 2004.

Daily Exercise Was Found To Reduce Prostate Cancer Cell Growth
Leung, P-S.,W.J. Aronson,T.H. Ngo, L.A. Golding and R.J. Barnard. Exercise alters the IGF axis in vivo and increases p53 protein in prostate tumor cells in vitro. J. Appl. Physiol. 96:450-454, 2004.

High-Fat, Refined Carbohydrate Diet Leads To Metabolic Syndrome and Lipid Disorders
Roberts, C.K. K. Liang, R.J. Barnard, C.H. Kim and N.D. Vaziri. HMG-CoA reductase, cholesterol 7a-hydroxylase, LDL receptor, SR-B1, and ACAT in diet-induced syndrome X. Kidney International 66:1503-1511, 2004.

The Pritikin Program Was Found To Control Insulin Resistance and Reduce IGF-1, Which Might Reduce the Risk For Many Cancers
Barnard, R.J. and Aronson, W.J. Diet, Exercise and Prostate Cancer. In: Prostate Cancer, J.N. Lucas ed. Nova Science, Hauppauge, N.Y. Chapt. I, 2004.

Prevention of cancer through lifestyle changes.
Barnard, R.J. eCAM Jol 1:233-239, 2004.

Low-Fat Diet Was Found To Be Linked With Slower Prostate Tumor Growth
Ngo, T.H., R.J. Barnard, P. Cohen, S. Freedland, C. Tran, F. deGregorio, Y.I. Elshimal, D. Heber and W.J. Aronson. Effect of isocaloric low-fat diet on human LAPC-4 prostate xenografts and the IGF axis in SCID mice. Clin. Cancer Res 9:2734,2003

The Importance of Studying a Low-Fat Diet High In Unrefined Carbohydrates
Roberts, C.K. and R.J. Barnard. Low-carbohydrate diets as compared with low-fat diets. New Engl J Med 349:1000,2003

The Benefits of Regular Exercise For the Prevention of Obesity and Cardiovascular-Related Diseases
Barnard, R.J. and J.O. Holloszy. The metabolic systems: Aerobic metabolism and substrate utilization in exercising skeletal muscle. in: The History of Exercise Physiology. C.M. Tipton editor, Oxford Press, New York, NY. p 292-320, 2003

A High-Fat, Refined Carbohydrate Diet Resulted In Hypertension and Salt Sensitivity; A Low-Fat Diet High In Unrefined Carbohydrates Did Not
Roberts, C.K., N.D. Vaziri, R.K. Sindhu and R.J. Barnard. A high-fat, refined carbohydrate diet affects renal NO synthase protein expression and salt sensitivity. J Appl. Physiol 94:941-946,2003

The Optimal Diet To Prevent Heart Disease Consists Largely of Unrefined, High-Fiber Carbohydrates
J.J. Kenney and J.S. Novick. Optimal diets to prevent heart disease. JAMA 289:1510, 2003

The Pritikin Program Was Found To Reduce Prostate Cancer Cell Growth By As Much As 45%
Barnard, R.J., T.H. Ngo, W.J. Aronson and L.A. Golding. A low-fat diet and/or strenuous exercise alters the IGF axis in vivo and reduces prostate tumor cell growth in vitro. Prostate 56:201-206,2003

The Pritikin Program Was Found To Reduce Cancer Cell Growth Via Decreases In IGF-1 and Increases In IGFBP-1
Ngo, T.H., R.J. Barnard, P. Cohen and W.J. Aronson. IGF-1 and Insulin-like growth factor binding protein-1 (IGFBP-1) modulate prostate cancer cell growth and apoptosis: Possible mediators for the effects of diet and exercise on cancer cell survival. Endocrinology 144:2319-2324,2003

The Pritikin Program Was Found To Lower Blood Pressure To Normal, Medication-Free Levels
Roberts, C.K., N.D. Vaziri, R.J. Barnard. Effect of diet and exercise intervention on blood pressure, insulin oxidative stress, and nitric oxide availability. Circulation 106:2530-2532,2002

Low-Fat Diet High In Unrefined Carbohydrates Ameliorated Negative Effects of High Fat, Refined Carbohydrate Diet On Fat Tissue and Cholesterol Levels
Roberts, C.K., R.J. Barnard, K.H. Lui and N.D. Vaziri. Effect of diet on adipose tissue and skeletal muscle VLDL receptors and LPL: Implications for obesity and hyperlipidemia. Atherosclerosis 161:133-141,2002

Conversion of Western-Style Diet To Pritikin Diet Lead To Normalization of Blood Pressure
Roberts. C.K., N.D. Vaziri, Z. Ni, X.Q. Wang and R.J. Barnard. Correction of long-term diet-induced hypertension and protein nitration by diet modification. Atherosclerosis 163:321-327,2002

High-Fat, Refined Sugar Diet Linked To Poorer Mental Function
Molteni, R., R.J. Barnard, Z. Ying, C.K. Roberts and F. Gomez-Pinilla. A high-fat, refined-sugar diet reduces BDNF, neuronal plasticity, and cognitive function. Neuroscience 112:803-814,2002

The Pritikin Program Was Found To Reduce Serum Hormones That Play A Role In Prostate Cancer Growth
Tymchuk, C.N., R.J. Barnard , T.H. Ngo and W.J. Aronson. The role of testosterone, estradiol, and insulin in diet and exercise-induced reductions in prostate cancer cell growth. Nutrition and Cancer 42 (1): 112-116, 2002

A High-Fat, High Sugar Diet Increased Fat Cell Size and Induced Obesity; A Low-Fat Diet High in Unrefined Carbohydrates Did Not
Roberts, C.K., J.J. Berger and R.J. Barnard. Long-term effects of diet on leptin, energy intake and activity in a model of diet-induced obesity. J.Appl. Physiol. 93:887-893,2002

The Pritikin Program Was Found To Retard the Growth of Prostate Cancer Cells and Induce Cancer Cell Death (Apoptosis)
Ngo, T.H., R.J. Barnard, C.N. Tymchuk, P. Cohen. And W.J. Aronson. Effect of diet and exercise on serum insulin, IGF-1, and IGFBP-1 levels and growth of LNCaP cells in Vitro. Cancer Causes & Control 13:929-935,2002

The Pritikin Program May Reduce the Risk For Prostate and Other Hormone-Related Cancers By Reducing the Insulin-Resistance Syndrome
Barnard, R.J., W.J. Aronson, C.N. Tymchuk and T.H. Ngo. Prostate cancer: Another aspect of the insulin resistance syndrome. Obesity Rev 3:303-308,2002

The Benefits of Regular Exercise For the Prevention of Obesity and Cardiovascular-Related Diseases
Barnard, R.J. and J.O. Holloszy. The metabolic systems: Aerobic metabolism and substrate utilization in exercising skeletal muscle. in: The History of Exercise Physiology. C.M. Tipton editor, Oxford Press, New York, NY. p 292-320, 2003

Switching From a High-Saturated-Fat, Refined Carbohydrate Diet To a Low-Fat, Unrefined Carbohydrate Diet Led To Normalization of Blood Pressure In Both Male and Female Rats
Roberts, C.K., N.D. Vaziri. Effects of estrogen on gender specific development of diet-induced hypertension. J. Appl Physiol. 91:2005-2009,2001

Metabolic Syndrome Induced By a High-Fat, Refined Carbohydrate Diet Was Reversed With Implementation Of a Low-Fat, Unrefined Carbohydrate Diet
Roberts, C.K., N.D. Vaziri, K.H. Liag and R.J. Barnard. Reversibility of long-term diet induced insulin resistance and metabolic syndrome characteristics. Hypertension 37:1323-1328,2001

High-Fat, High-Sugar Diet Induced Insulin Resistance; Low-Fat, Unrefined Carbohydrate Diet Did Not
Youngren, J.F., J.Paik and R.J. Barnard. Impaired insulin receptor autophosphorylation is an early defect in fat-fed, insulin-resistant rats. J. Appl. Physiol. 91:2240-2247,2001

The Pritikin Program Resulted In Serum Changes That Significantly Reduced the Growth Of Prostate Cancer Cells In Vitro.
Tymchuk, C.N., R.J. Barnard, D. Heber and W.J. Aronson. Evidence for an inhibitory effect of diet and exercise on prostate cancer cell growth. J. Urol . 166:1185-1189,2001

Both Aerobic and Resistance Exercise Help Control Type 2 Diabetes and Reduce Risk For Macrovascular Complications
Barnard, R.J. American College of Sports Medicine Position Stand on Exercise and Type 2 Diabetes, AJMS 2 (6):364-367,2000

A High-Fat, Refined Carbohydrate Diet Inactivated Nitric Oxide and Induced Hypertension; A Low-Fat, Unrefined Carbohydrate Diet Did Not
Roberts, C.K., N.D. Vaziri, X.Q. Wang, and R.J. Barnard. NO inactivation and hypertension induced by a high-fat, refined carbohydrate diet. Hypertension 36:423-429,2000

A High-Fat, High-Sugar Diet Induced Obesity and High Levels of Insulin and Homocysteine; A Low-Fat, Unrefined Carbohydrate Diet Did Not
Fonseca, V., A. Dicker-Brown, S. Ranganathan, W. Song, R.J. Barnard, L. Fink and P.A. Kern. Effect of a high-fat-sucrose diet on enzymes of homocysteine metabolism in the rat. Metabolism 49:736-741,2000

The Pritikin Program Increased Levels Of Sex Hormone-Binding Globulin and Reduced Levels of Insulin, Which Should Reduce the Risk for Breast Cancer In Postmenopausal Women
Tymchuk, C.N., S.B. Tessler and R.J. Barnard. Changes in sex hormone-binding globulin, insulin and serum lipids in postmenopausal women on a low-fat, high-fiber diet combined with exercise. Nutrition and Cancer 38:158-162,2000

Numerous Studies Have Documented the Value of Exercise In the Treatment of Peripheral Vascular Disease
Barnard, R.J. The role of exercise in the detection and treatment of peripheral vascular disease. In. Exercise and the Heart in Health and Disease . R. J. Shephard and H.S. Miller eds. Marcel Dekker, Inc. New York, N.Y. , 1999

The Pritikin Program Was Found To Markedly Improve Cholesterol Levels of Postmenopausal Women
Barnard, R.J. and S.B. Inkeles. Effects of an intensive diet and exercise program on lipids in postmenopausal women. Women's Health Issues 9:155-161,1999

Hypertension Induced By a High-Fat, High-Sugar Diet Was Associated With Impaired Endothelial Function, Which Increases the Risk of Cardiovascular Disease. Switching To a Low-Fat, Unrefined Carbohydrate Diet Reversed This Effect.
Reil, T.D., R.J. Barnard, V.S. Kashyap, C.K. Roberts and H.A. Gelabert. Diet induced changes in endothelial dependent relaxation of the rat aorta. J Surg Res 85:96-100,1999

Attenuated Hormone Sensitive Lipase Activity Does Not Appear To Play a Role In the Development of Obesity
Berger, J.J. and R.J. Barnard. Effect of diet on fat cell size and hormone sensitive lipase activity. J Appl Physiol. 87:227-232,1999

A Summary of Research Documenting the Effectiveness of the Pritikin Program For the Prevention and Control of Coronary Heart Disease
Barnard, R.J. A carbohydrate diet to prevent and control coronary heart disease. Pritikin was Right. ACSM's Health and Fitness J. 3:23-26,1999

Exercise Increases Levels of Nitric Oxide, a Beneficial Chemical That Expands Blood Vessels, Increases Blood Flow, and Squelches Plaque Growth
Roberts, C.K., R.J. Barnard, A. Jasman and T.W. Balon. Acute exercise increases nitric oxide synthase activity in skeletal muscle. Am J Physiol 277 (Endocrinol. Metab 40 ) E390-E394,1999

A Summary of Research Documenting the Benefits of Low-Fat, High Fiber Diets For the Prevention/Reversal of Coronary Artery Disease
Kenney, J.K., R.J. Barnard and S. Inkeles. Very-low-fat diets do not necessarily promote small, dense LDL particles. Am J Clin Nutr. 70:423,1999

The Scientifically Documented Value Of a Very-Low-Fat Diet High In Unrefined Carbohydrates For the Prevention and Control of Coronary Heart Disease
Barnard, R.J. Very-low-fat diets . Circulation 100:1011-1013,1999

A High-Fat, High-Sugar Diet Induced Insulin Resistance Before Other Manifestations of the Metabolic Syndrome, Indicating That Diet, Not Obesity, Is the Underlying Cause of the Syndrome. A Low-Fat, Unrefined Carbohydrate Diet Did Not Induce Insulin Resistance.
Barnard, R.J., C.K. Roberts, S.M. Varon and J.J. Berger, Diet-induced insulin resistance precedes other aspects of the metabolic syndrome. J Appl Physiol, 84:1311-1315,1998

The Pritikin Program May Reduce the Risk For Prostate Cancer By Altering Serum Hormones That Affect Prostate Cancer Growth
Tymchuk, C.N., S.B. Tessler, W.J. Aronson and R.J. Barnard, Effects of diet and exercise on insulin, sex hormone-binding globulin and prostate-specific antigen. Nutrition and Cancer, 31:127-131,1998

Switching From a High-Fat Refined Carbohydrate Diet To a Low-Fat Unrefined Carbohydrate Diet Reversed Insulin Resistance, Decreasing the Risk of Type 2 Diabetes
Barnard, R.J., J.F. Youngren and S.H. Scheck, Reversibility of diet-induced skeletal muscle insulin resistance. Diabetes Res, 32:213-221,1997

The Pritikin Program Was Found To Substantially Enhance the Effectiveness of Statin Therapy
Barnard, R.J., S.C. DiLauro and S.B. Inkeles, Effects of intensive diet and exercise intervention in patients taking cholesterol-lowering drugs. Am J Cardiol 79:1112-1114,1997

Regular Exercise Enhanced Glucose Transport Via Increased Nitric Oxide
Roberts, C.K., R.J. Barnard, S.H. Scheck and T. W. Balon, Exercise-stimulated glucose transport in skeletal muscle is nitric oxide dependent. Am J Physiol 273:E220-E225,1997

The Pritikin Program Was Found To Substantially Reduce Total Cholesterol, LDL Cholesterol, Triglycerides, Glucose, Oxidation Levels, and Body Weight
Beard, C.M., R.J. Barnard, D.C. Robbins, J.M. Ordovas and E.J. Schaefer, Effects of diet and exercise on qualitative and quantitative measures of LDL and its susceptibility to oxidation. Arterioscler Thromb Vasc Biol, 16:201-207,1996

In Healthy Premenopausal Women, the Pritikin Eating Plan Reduced Estradiol and Estrone Levels Without Affecting Ovulation, Thereby Providing a Rationale For The Prevention Of Breast Cancer
Bagga, D., J.M. Ashley, S.P. Geffrey, H-J. Wang, R.J. Barnard, S. Korenman and D. Heber, Effects of a very low fat, high fiber diet on serum hormones and menstrual function: Implications for breast cancer prevention. Cancer, 76:2491-2496,1995

Moderate Exercise/Lean Protein Diet Produced Beneficial Effects On Bone Mass
Zernicke, R.F., G.J. Salem, R.J. Barnard, J.S. Woodward Jr., J.W. Meduski and J.D. Meduski, Adaptations of immature trabecular bone to exercise and augmented dietary protein. Med Sci Sports Exer, 27:1486-1493,1995

Prevention of Osteoporosis
Exercise Was Found To Maintain Bone Strength
Li, K-C, R F. Zernicke, R.J. Barnard and A.F-Y. Li, Response of immature diabetic bone-ligament junctions to insulin and exercise. Clin Biomech, 10 : 331-336,1995

High-Fat, Refined Carbohydrate Diet, Not Aging, Caused Insulin Resistance
Barnard, R.J., J.F. Youngren and D.A. Martin, Diet, not aging, causes skeletal muscle insulin resistance. Gerontology, 41:205-211,1995

The Pritikin Program Was Found To Substantially Improve Coronary Artery Blood Flow As Well As Reduce Total Cholesterol, LDL Cholesterol, and Triglycerides
Czernin, J., R.J. Barnard, K.T. Sun, J. Krivokapich, E. Nitzsche, D. Dorsey, M.E. Philps and H.R. Schelbert, Effect of short-term cardiovascular conditioning and low-fat diet on myocardial blood flow and flow reserve. Circulation, 92:197-204,1995

A Long-Term, High-Fat-Sucrose Diet Had Significant Adverse Effects On Bone Strength And Mechanics; A Long-Term Low-Fat Unrefined Carbohydrate Diet Had No Adverse Effects On Bone
Zernicke, R.F., G.J. Salem, R J. Barnard and E. Schramm, Long-term, high-fat-sucrose diet alters rat femoral neck and vertebral morphology, bone mineral content, and mechanical properties. Bone, 16:25-31,1995

Muscle Glucose Transport Was Fully Stimulated By Exercise
Youngren, J.F. and R.J. Baranard, Effects of acute and chronic exercise on skeletal muscle glucose transport in aged rats. J Appl Physiol, 78,1750-1756,1995

The Pritikin Program Was Found To Control Type 2 Diabetes. 71% Of Subjects Taking Oral Drugs and 39% Taking Insulin Were Able To Discontinue Their Medications. Of Those Not Taking Medication, 76% Reduced Their Fasting Glucose Levels To Normal Levels.
Barnard, R.J., T. Jung and S.B. Inkeles, Diet and exercise in the treatment of NIDDM - the need for early emphasis. Diabetes Care, 17:1469-1472,1994

A Low-Fat, High-Fiber Diet Was Found To Modulate Lipids In Ways That May Be Cancer-Protective
Bagga, D., J.M. Ashley, S. Geffrey, Hei-Jung, R.J. Barnard, R. Elashoff and D. Heber, Modulation of serum and breast duct fluid lipids by a very low-fat, high-fiber diet in premenopausal women. JNCI, 86:1419-1421,1994

The Pritikin Program Was Found To Control the Metabolic Syndrome Within Three Weeks
Barnard, R.J. and, S.J. Wen, Exercise and diet in the prevention and control of the metabolic syndrom. Med Sports 18:218-228,1994

The Pritikin Program Was Found To Relieve Or Significantly Reduce Claudication Pain
Barnard, R.J., Physical activity, fitness and claudication. In Physical Activity, Fitness and Health 1992 Proceedings. C. Bouchard, R.J. Shephard and T. Stephens, eds. Human Kinetics, Champaign, IL. p 622-632, 1994.

Control of Diabetes May Promote Bone Health
Li, K.C., R. F. Zernicke, R.J. Barnard, A.F.X. Li, P. Campbell. Effects of mild diabetes on immature cortical bone. Clin Biomech, 8:49-51,1993

A High-Fat, Sucrose Diet Produced Several Risk Factors For Cardiovascular Disease In Rats; A Low-Fat Unrefined Carbohydrate Diet Produced No Risk Factors
Barnard, R.J., D.J. Faria, J.E. Menges, and D.A. Martin, Induction of hyperinsulinemia and related atherosclerotic risk factors by a high-fat, sucrose diet. Atherosclerosis, 100: 229-239, 1993.

A Diet Rich In Fat and Sucrose Was Found To Have Negative Effects On Growing Bone; A Low-Fat Unrefined Carbohydrate Diet Had No Negative Effects
Li, K-C, R.F. Zernicke, R.J. Barnard and A.F-Y Li. Response of immature bone-ligament junction to a high-fat, sucrose diet. Clin Biomech, 8:163-165, 1993

Severe Diabetes Was Found To Adversely Affect Growing Bone
Hou. J. C-H., R.F. Zernicke, and R.J. Barnard. Effects of severe diabetes on immature rat femoral neck. J Orthop Res, 11: 263-271, 1993.

Diets High In Sucrose and Fat (HFS) Have Been Associated With Changes In Calcium Metabolism. This Study Suggests a HFS Diet May Adversely Affect Vertebral Body Mechanical Integrity And Strength. A Low-Fat Unrefined Carbohydrate Diet Caused No Adverse Effects.
Salem, G.J., R.F. Zernicke, R.J. Barnard. Diet related changes in mechanical properties or rat vertebrae. Am J Physiology, 262:R318-R321,1992

The Pritikin Program Was Found To Control Diabetes and Hypertension and, For Many, Eliminate the Need For Drugs
Barnard, R.J., E.J. Ugianskis, D.A. Martin. The effect of an intensive diet and exercise program on patients with NIDDM and hypertension. J Cardioresp Rehab, 12:194-201, 1992

This Study Examined the Effects of Aging On Insulin Responsiveness
Barnard, R.J., L.O. Lawani, D.A. Martin, J.F. Youngren, R. Singh, S.H. Scheck. Effects of maturation and aging on the skeletal muscle glucose transport system. Am J Physiol, 262:E619-E626, 1992

This Letter Summarizes the Benefits Of Lifestyle Changes For Lowering Lipid Levels
P. A. Chapdelaine Jr, Response to "Letter to the Editor". Arch Intern Med, 152:1721-1723,1992

The Pritikin Program Was Found To Control Hyperinsulenemia and Related Atherosclerotic Risk Factors, Including High Cholesterol and Triglyceride Levels
Barnard, R.J., E.J. Ugianskis, D.A. Martin, S.B. Inkeles. Role of diet and exercise in the managment of hyperinsulenemia and related atherosclerotic risk factors. Am J Cardiol, 69:440-444,1992.

Strenuous Exercise Enhanced Bone Density
Li, K-C., R.F. Zernicke, R.J. Barnard and A. F-Y Li. Differential response of rat limb bones to strenuous exercise. J Appl Physiol, 70:554-560,1991.

Patients With Type 2 Diabetes Had a Severe State Of Insulin Resistance In Glucose Transport
Scheck, S.H., R.J. Barnard, L.O. Lawani, J.F. Youngren, D.A. Martin and R. Singh. Effects of NIDDM on the glucose transport system in human skeletal muscle. Diabetes Res, 16:111-119,1991.

Among 4,587 People, the Pritikin Program Was Found To Reduce Total Cholesterol On Average 23%, LDL Cholesterol 23%, and Triglycerides 33% In Three Weeks. Body Weight Was Also Significantly Reduced. Follow-Up Studies For 18 Months Showed Continued Compliance.
Barnard, R.J. Effects of life style modification on serum lipids. Arch Int Med, 151:1389-1394,1991.

Diabetes Was Found To Adversely Affect Thigh Form and Function
Hou, J.C-H., R.F. Zernicke and R.J. Barnard. Experimental diabetes, insulin treatment and femoral neck morphology and biomechanics in rats . Clin Orthop, 264:278-85,1991.

The Pritikin Program Was Found To Lower Estradiol Levels On Average 40%. Estradiol Is a Hormone That In Excess Stimulates the Growth of Breast Tumors
Heber, D., J.A. Ashley, D.A. Leaf, R.J. Barnard. Reduction in serum estradiol in postmenopausal women given free access to a low-fat, high-carbohydrate diet. Nutrition, 7:137-40,1991.

The Pritikin Program Was Found To Significantly Improve Blood Circulation and Relieve Pain of Peripheral Vascular Disease
Barnard, R.J. Use of exercise and diet to fight peripheral vascular disease; Your Patient and Fitness, 5:12-16,1990.

Daily Insulin Treatment In Diabetic Animals Corrected Some Defects In Glucose Transport, But Maximum Insulin Stimulation Was Still Significantly Below Values For Nondiabetic Animals, Indicating That Prevention Of Type 2 Diabetes, Rather Than Control, Is Preferable.
Barnard, R.J., D. S. Kartel, J.F. Youngren and D.A. Martin. Effects of streptozotocin-induced diabetes on glucose transport in skeletal muscle. Endocrinology, 126:1921-1926,1990.

The Pritikin Program Was Found To Significantly Reduce Total Cholesterol, LDL Cholesterol, and Triglycerides In Three Weeks
Barnard, R.J. Short-term reductions in serum lipids through diet and exercise. New Engl J Med, 323 (16): 1142,1990.

High-Fat, High Sucrose Diets Were Found To Adversely Affect Bone Structure and Strength
Hou, J.C-H., R.F. Zernicke and R.J. Barnard. High-fat sucrose diet effects in femoral neck geometry and biomechanics. Clin Biomech, 5:162,1990.

Strenuous Aerobic Exercise Impacts Bone Growth In Various Ways
Hou, J. C-H, G.J. Salem, R.F. Zernicke and R.J. Barnard. Structural and mechanical adaptations of immature trabecular bone to strenuous exercise. J Appl Physiol, 69:1309-1314,1990.

A High-Fat, High-Sucrose Diet Was Found To Adversely Affect Bone Health
Li, K-C, R.R. Zernicke, R.J. Barnard and A. F-Y Li. Effects of a high-fat, sucrose diet on cortical bone remodeling and biomechanics. Calcif Tissue Int, 47:308-313,1990.

The Pritikin Program Was Found To Significantly Reduce Levels of Plasminogen and Apolipoprotein B, Which May Reduce the Risk of Coronary Artery Disease
Mehrabian, M., J. Peter, R.J. Barnard and A. Lusis. Dietary regulation of fibrinolytic factors. Atherosclerosis, 84:25,1990.

The Benefits of a High-Fiber, Low-Calorie-Dense Diet Vs a High-Monounsaturated Diet For Weight Control and Prevention of Type 2 Diabetes
Kenney, J., M. Rosenthal, S. Inkeles and R.J. Barnard. Letter to the Editor. New Engl J Med, 320: 536,1989.

The Benefits of Exercise In Maintaining Healthful Blood Glucose Levels
Sternlicht, E., R.J. Barnard and G.K. Grimditch. Exercise and insulin stimulate skeletal muscle glucose transport through different mechanisms. Am J Physiol, 256: E227-E320,1989.

An Examination of How Exercise Stimulates Glucose Transport
Sternlicht, E., R.J. Barnard and G.K. Grimditch. B-adrenergic receptors are not responsible for exercise stimulation of glucose transport. J Appl Physiol, 66:2419-2422,1989.

The Benefits of Exercise In Treatment, Including Pain Management, of Claudication (Peripheral Vascular Disease)
Barnard, R.J. and J.A. Hall. The role of exercise in the detection, treatment and evaluation of patients with peripheral vascular disease; in Exercise and Modern Medicine: Testing and Prescription in Health and Disease. B.A. Franklin, S. Gordon, G.C. Timmis, eds, Williams & Wilkins, Baltimore, MD.,1988

The Pritikin Program Was Found To Effect Changes In Serum Apoproteins That Improved Arterial Health
Barnard, R.J., J.B. Peter, J. Hall and C. Kinsella. Effects of a short-term diet and exercise program on serum apoproteins. J Appl Nutr, 40:5-12,1988.

The Pritikin Program Was Found To Significantly Improve Risk Factors For Coronary Artery Disease
Barnard, R.J., R. Pritikin, R. Rosenthal and S. Inkeles. Pritikin Approach to Cardiac Rehabilitation; Rehabilitation Medicine, J. Goodgold, ed., C.V. Mosby Company, St. Louis, MO.,1988

A Low-Fat Diet High In Unrefined Carbohydrates Did Not Induce Insulin Resistance; Other Diets Did, Including High-Fat, High-Sugar Diets
Grimditch, G.K., R.J. Barnard, L. Hendricks and D. Weitzman. Peripheral insulin sensitivity as modified by diet and exercise training. Am J Clin Nutr, 48:38-43,1988.

The Pritikin Eating Plan Was Found To Decrease Concentrations of Fecal Bile Acids and Neutral Sterols
Reddy, B. S., A. Engle, B. Simi, L.T. O'Brien, R.J. Barnard, N. Pritikin and E. L. Wynder. Effect of low-fat, high carbohydrate, high-fiber diet on fecal bile acids and neutral sterols . Preventive Med ,17:432-439, 1988.

An Examination of the Effect Of Insulin Stimulation On Glucose Transport
Sternlicht, E., R.J. Barnard and G.K. Grimditch. Mechanism of insulin action on glucose transport in rat skeletal muscle. Am J Physiol, 254:E633-E638:1988.

An Examination of Dietary Factors That Increase Total Insulin Binding Activity
Whitson, R.H., G.K. Grimditch, E. Sternlicht, S.A. Kaplan, R.J. Barnard and K. Itakura. Characterization of rat skeletal muscle sarcolemmal insulin receptors and a sarcolemmal insulin binding inhibitor; J Biol Chem, 263:4789-4794,1988.

In Men With High Lipid Levels, the Pritikin Eating Plan Significantly Reduced Cholesterol and Triglyceride Levels, Platelet Aggregation, and Thromboxane Formation
Barnard, R.J., J.A. Hall, A. Chaudhari, J.E. Miller and M.A. Kirschenbaum. Effects of low-fat, low-cholesterol diet on serum lipids, platelet aggregation and thromboxane formation. Prostaglandins Leukotrienes and Medicine, 26:241-252,1987.

At Autopsy, Nathan Pritikin’s Arteries Were Found To Be Free of Coronary Artery Disease, Providing Compelling Evidence That the Heart Disease He Had Been Diagnosed With 20 Years Earlier Had Been Reversed By His Diet-And-Exercise Program
Barnard, R.J., S. Inkeles and K.A. Foon. Nathan Pritikin's Heart. Nutrition Today, 22:39,1987.

Insulin Levels and Insulin Resistance Were Found To Be Markedly Higher In Rats Consuming a High-Fat, High-Sugar Diet Versus Those Consuming a Low-Fat, High-Unrefined-Carbohydrate Diet
Grimditch, G.K., RJ. Barnard, E. Sternlicht, R.H. Whitson and S.A. Kaplan. Effect of diet on insulin binding and glucose transport in rat sarcolemmal vesicles. Am J Physiol, 252: E420-E425, 1987.